Effect of Verapamil Administration on Hypoxic Human Fetal Brain after Lactate detection by 1H Magnetic Resonance Spectroscopy (1HMRS)

Publicado: 26-03-2004

   Sahyly Siurana

Instituto de Resonancia Magnética “San Román”.

   Ronald Ortega

Policlínica Metropolitana. Departamento de Ecocardiografía Fetal.

   Freddy Guevara

Jefe del Servicio de Neonatología. UCV. Hospital Universitario de Caracas.

   Humberto Azpúrua

Investigador. Instituto Venezolano de Investigaciones Científicas y Tecnológicas (IVIC)

   Arturo Alvarado R. Pisani

Instituto de Resonancia Magnética "San Román".

Resumen

The purpose of this study was to evaluate the effect of verapamil administration on Human Fetuses in High Risk Pregnancies (FHRP) by Proton Magnetic Resonance Spectroscopy (1HMRS) after Lactate identification. Two 1HMRS studies were performed on a 1.5 Tesla system using the body RF coil: the first one was done between 30-31 weeks of gestation and the second between 34-35 weeks after verapamil administration. The results obtained in the second 1HMRS study show a significant decrease in Lactate signal in FHRP compared with the first study. This reduction could be related to a more oxygen availability due to the verapamil vasodilator effect in FHRP.

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